New Medical Treatments Approved in 2024
- Keytruda (pembrolizumab) in combination with chemotherapy for patients with inoperable locally advanced or metastatic triple-negative breast cancer (PD-L1 CPS ≥10) without prior systemic treatment for metastatic disease.
- Lynparza (olaparib) with bevacizumab for first-line maintenance treatment of advanced ovarian, fallopian tube, or primary peritoneal cancer in patients with high-grade epithelial carcinoma and homologous recombination deficiency (HRD+), but without BRCA1/2 mutations (BRCAwt).
- Ayvakyt (avapritinib) for gastrointestinal stromal tumors (GIST) with a D842V mutation in PDGFRA where the disease is inoperable or metastatic.
- Imfinzi (durvalumab) with gemcitabine and cisplatin for first-line treatment of advanced bile duct and gallbladder cancer.
- Tagrisso (osimertinib) as adjuvant treatment for EGFR-mutated non-small cell lung cancer after surgery.
- Keytruda (pembrolizumab) as adjuvant treatment for kidney cancer with high recurrence risk post-nephrectomy.
- Enfortumab vedotin for adult patients with locally advanced or metastatic urothelial cancer previously treated with platinum-based chemotherapy and a PD-1/L1 inhibitor (second line). For patients with performance status 0 or 1.
- Two treatments for extensive-stage small cell lung cancer:
- Imfinzi (durvalumab) with chemotherapy
- Tecentriq (atezolizumab) with chemotherapy
(Recommendations apply to patients in good general condition – performance status 0 or 1)
- Opdivo (nivolumab) with platinum-based chemotherapy (gemcitabine and cisplatin) for first-line treatment of patients with locally advanced or metastatic urothelial carcinoma (bladder and urinary tract cancer). For patients in good general condition (performance status 0 or 1).
New guidelines/instructions (VIP) include:
- Treatment of medullary spinal cord compression
- Nausea management in medical cancer treatment
- Management of skin toxicity from EGFR - treatment
- All newly released national quality database reports have been reviewed. Exsample: Selected
Results from National Clinical Databases
- New standards in the Head and Neck cancer database have been assessed, but results are pending further follow-up.
A 5-year survival analysis was conducted for all patients with metastatic disease receiving first- and second-line treatments. Survival is at or above international standards (Appendix 4).5-Year Survival for Patients with Metastatic Disease